The connection anywhere between BMD and you can pounds is more powerful than between Bmi and you will BMD

The connection anywhere between BMD and you can pounds is more powerful than between Bmi and you will BMD

step three.step 3. Chance Affairs

Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).

Both Body mass index and pounds had been coordinated that have BMD, and you can BMC signs in addition to most effective Pearson’s correlation coefficients was indeed located between weight and you may BMC as a whole hip and you may trochanter regions and you can brand new weakest ones were anywhere between Body mass index and you may femoral neck BMC. The brand new correlations anywhere between many years and BMD and you can BMC signs was basically negative (Desk cuatro).

Age-adjusted proportion away from BMD and you will BMC adaptation informed me by the Bmi and weight was revealed from inside the Desk 5. Lbs had a tendency to show greater variations in BMD and BMC shipment whatsoever the fresh learnt skeletal internet sites compared to Bmi. This is mirrored of the steeper slope (?) of your respective linear regression contours. The number one difference in BMD and BMC distribution seemed from the trochanter BMC followed by lumbar BMC to own lbs. Pounds is an important predictor regarding BMD and you will BMC version inside the elderly Iranian boys.

4. Dialogue

In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.

The fresh components whereby fatty tissue exerts positive effects into BMD status aren’t entirely clear. Brand new putative mechanism benefits from fat to have skeletal stability most likely lives in new character of a lot adipokines within the bone restorations using affect both formation and you may resorption. Recently, limbs might have been thought an endocrine organ impacting body weight handle and you can glucose homoeostasis from tips out-of limbs-derived situations particularly osteocalcin and you may osteopontin [23, 34–36]. The brand new putative crosstalk ranging from lbs therefore the skeleton constitutes a homoeostatic views program in which adipokines and particles secreted by osteoblasts and you may osteoclasts depict the link of an active bone-adipose axis [34–36]. Obesity is additionally of this BMD by the transformation of androgen in order to estrogen , and therefore advances bone size both in visitors [38, 39] and preserves match plasma amounts of insulin and you may controlling items also insulin-such development grounds-step 1, leptin, and you can adiponectin . At the same time, being obese provides cushioning towards stylish in case of a beneficial slide . Yet not, new mechanisms wherein most of these situations occur continue to be uncertain.

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